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OBJECTIVES@#To compare the short-, mid-, and long-term outcomes in patients with esophageal cancer between minimally invasive esophagectomy via Sweet approach in combination with cervical mediastinoscopy (MIE-SM) and minimally invasive esophagectomy via McKeown approach (MIE-MC), and to evaluate the value of MIE-SM in the surgical treatment of esophageal cancer.@*METHODS@#A prospective, nonrandomized study was adopted. A total of 65 esophageal cancer patients after MIE-SM and MIE-MC from June 2014 to May 2016 were included. Among them, 33 patients underwent MIE-SM and 32 patients underwent MIE-MC. Short-term outcomes (including the duration of surgery, intraoperative blood loss volume, ICU stay time, postoperative complications, postoperative hospital stay, reoperation, open surgery, number of dissected lymph nodes, and 30-day mortality), mid-term outcomes, [including Quality of Life Core Questionnaire (QLQ-C30) and the esophageal site-specific module (QLQ-OES18)], long-term outcomes [including overall survival and disease-free survival] were compared between the 2 groups.@*RESULTS@#Radical resection (R0) were achieved in all patients. There were no significant differences in the duration of surgery, intraoperative blood loss volume, ICU stay time, postoperative complications, and postoperative hospital stay between the 2 groups (all @*CONCLUSIONS@#MIE-SM appears to be a safe surgical approach, which may get better quality of life, suffer less pain, and can achieve the same therapeutic effect as MIE-MC. Therefore, MIE-SM should be considered as a valuable approach for the treatment of middle and lower esophageal cancer.
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Humans , Esophageal Neoplasms/surgery , Esophagectomy , Laparoscopy , Mediastinoscopy , Minimally Invasive Surgical Procedures , Postoperative Complications/epidemiology , Prospective Studies , Quality of Life , Retrospective Studies , Treatment OutcomeABSTRACT
Background: Cervical cancer is one of many health care ironies. Better survival rates demand better quality of life (QoL). The aim of present study was to determine the change in QoL of cervical cancer patients due to treatment.Methods: An observational prospective study was conducted from July 2017 to June 2018 among 80 new cervical cancer patients without any prior history of treatment for cervical cancer, attending radiotherapy department of a tertiary care centre of West Bengal using a semi-structured schedule and European Organization for Research and Treatment of Cancer (EORTC) quality of life questionnaire (QLQ). Information was collected on socio-demographic and clinical aspects and QoL domains. Those with history of surgery for cervical cancer, advanced stage of disease were excluded. EORTC QLQ was administered at baseline and one month after completion of treatment. Data was analysed by percentage, means±standard deviation, range and Wilcoxon signed rank test etc. using SPSS-16.Results: Only 60 patients could be analysed as 10 patients died and 10 lost to follow-up. After treatment there was a significant improvement in global health, physical, emotional and cognitive functioning as well as decrease in symptoms like fatigue, pain, insomnia, appetite loss and constipation along with worsening of financial difficulties. There was significant improvement in body image, decrease in problems of symptom experience, peripheral neuropathy and menopausal symptoms after treatment.Conclusions: The cervical cancer patients show an overall improvement in their QoL in most of the domains after one month of treatment except worsening of financial difficulties.
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@#Prostate cancer is forth most common diagnosed tumors in Malaysian male. The use of a self-reported, quality of life assessment is important for clinical practice, care taker and researcher to evaluate the level of quality of life. The aim of this study was to measure the internal consistency of the translated Malay Language EORTC QLQ-C30 and EORTC PR-25 questionnaires among prostate cancer patient at National University of Malaysia hospital in Kuala Lumpur, Malaysia. Methods This was a cross sectional study conducted between July 2017 and Dec 2017. The respondent comprised of 110 Malaysian prostate cancer patients who were under follow up at Urology and Oncology Clinic. Sets of translated Malay language EORTC QLQ C30 and EORTC PR-25 consisted of functional, symptom and global health status domains were administered to assess their quality of life. Results The translated questionnaires were acceptable by 110 respondents. Cronbach`s α coefficient result were 0.913 (EORTC QLQ-C30) and 0.829 (EORTC PR25) respectively suggested that this instrument had good internal consistency. Conclusions Our study confirmed that translated Malay language EORTC QLQ-C30 and QLQ-PR25 questionnaires are acceptable, reliable and valid instrument to be used among Malaysian prostate cancer patients.
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Objetivo: Evaluar la relación entre los determinantes sociales de la salud y la calida de vida de mu-jeres con diversos tipos de cáncer de 60 años y más.Metodología: Estudio cuantitativo, transversal, con enfoque descriptivo - correlacional. Se aplicó escala de calidad de vida QLQ-C30 y fi cha de datos sociodemográfi cos a 70 mujeres de 60 años y más diagnosticadas con cáncer, de un hospital público, provincia de Concepción, región del Biobío, Chile.Resultado: El promedio de edad de las mujeres fue 69,9 años (DE=6,8), el cáncer predominante fue el de mama, más del 50% de ellas estaba con tratamiento de quimioterapia y un 72% en etapa avanza-da del cáncer (III-IV). La calidad de vida en las escalas de funcionamiento físico, de rol, emocional, cognitivo y social, obtuvo valores sobre 63/100 puntos y en la de salud global sobre 65/100 puntos; los síntomas de dolor y fatiga obtuvieron altos puntajes comparados con otros. Existió relación es-tadísticamente signifi cativa con 2 Determinantes Sociales Estructurales (educación y ocupación), y con 3 Intermediarios (tenencia y estado de la vivienda, y satisfacción de ingreso). Conclusión: Los puntajes en la escala de calidad de vida indican una tendencia hacia una buena calidad de vida. Sin embargo, es impactada negativamente por la educación, ocupación, estado de la vivienda y satisfacción con ingresos percibidos. Es necesario enfocarse en estas determinantes sociales en la valoración y cuidado de la mujer adulta mayor con cáncer, para proponer estrategias interdisciplinarias que mejoren efectivamente su bienestar y calidad de vida.
Objective: To evaluate the relationship between the social determinants of health and the quality of life of women with various types of cancer aged 60 and over.Methodology: Quantitative, transversal study, with descriptive correlational approach. The QLQ-C30 quality of life scale and sociodemographic data sheet were applied to 70 women aged 60 years and over diagnosed with cancer, from a public hospital, Concepción province, Biobío region, Chile. Result: The average age of the women was 69.9 years (SD = 6.8), the predominant cancer was the breast, more than 50% of them were with chemotherapy and 72% in the advanced stage of the cancer (III -IV). The quality of life in the scales of physical, role, emotional, cognitive and social functioning, obtained values over 63/100 points and in the overall health over 65/100 points; the symptoms of pain and fatigue obtained high scores compared with others. There was a statistically signifi cant relationship with 2 Structural Social Determinants (education and occupation), and with 3 Interme-diaries (tenure and housing status, and income satisfaction). Conclusion: The scores on the quality of life scale indicate a trend towards a good quality of life. However, it is negatively impacted by education, occupation, housing status and satisfaction with income received. It is necessary to focus on these social determinants in the assessment and care of elderly women with cancer, to propose interdisciplinary strategies that eff ectively improve their well-being and quality of life
Objetivo: Avaliar a relação entre os determinantes sociais da saúde e a qualidade de vida de mulhe-res com vários tipos de câncer com 60 anos ou mais. Metodologia: Estudo quantitativo, transversal, com abordagem descritivo-correlacional. escala de qualidade de vida QLQ-C30 foi aplicado e dados sociodemográfi cos fi cha 70 mulheres com idades entre 60 e mais velhos diagnosticados com câncer, um hospital público na província de Concepcion, Biobio Region, Chile.Resultado: A idade média das mulheres era de 69,9 anos (DP = 6,8), o cancro da mama predomi-nante foi mais do que 50% de las foram com quimioterapia e 72% em estágio avançado de cancro (III -IV). A qualidade de vida nas escalas de funcionamento físico, papel, emocional, cognitivo e social, obteve valores acima de 63/100 pontos e na saúde geral acima de 65/100 pontos; os sintomas de dor e fadiga obtiveram pontuações altas em comparação com outros. Houve uma relação estatisticamente signifi cativa com 2 Determinantes Sociais Estruturais (educação e ocupação) e com 3 Intermediários (estabilidade e status de moradia e satisfação com a renda). Conclusão: Os escores na escala de qualidade de vida indicam tendência a uma boa qualidade de vida. No entanto, é impactado negativamente pela educação, ocupação, status de moradia e satis-fação com a renda recebida. É necessário enfocar esses determinantes sociais na avaliação e cuidado de mulheres idosas com câncer, para propor estratégias interdisciplinares que efetivamente melho-rem seu bem-estar e qualidade de vida.
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Humans , Quality of Life , Nursing , Neoplasms , Social Determinants of HealthABSTRACT
<p><b>OBJECTIVE</b>The primary aim of the study was to compare two nutritional status evaluation tools: the Patient-Generated Subjective Global Assessment (PG-SGA) and Nutritional Risk Screening (NRS-2002). Using the European Organization for Research and Treatment of Cancer Quality of Life Core Questionnaire 30 (EORTC QLQ-C30), the second aim was to provide constructive advice regarding the quality of life of patients with malignancy.</p><p><b>METHODS</b>This study enrolled 312 oncology patients and assessed their nutritional status and quality of life using the PG-SGA, NRS-2002, and EORTC QLQ-C30.</p><p><b>RESULTS</b>The data indicate that 6% of the cancer patients were well nourished. The SGA-A had a higher sensitivity (93.73%) but a poorer specificity (2.30%) than the NRS-2002 (69.30% and 25.00%, respectively) after comparison with albumin. There was a low negative correlation and a high similarity between the PG-SGA and NRS-2002 for evaluating nutritional status, and there was a significant difference in the median PG-SGA scores for each of the SGA classifications (P < 0.001). The SGA-C group showed the highest PG-SGA scores and lowest body mass index. The majority of the target population received 2 points for each item in our 11-item questionnaire from the EORTC QLQ-C30.</p><p><b>CONCLUSION</b>The data indicate that the PG-SGA is more useful and suitable for evaluating nutritional status than the NRS-2002. Additionally, early nutrition monitoring can prevent malnutrition and improve the quality of life of cancer patients.</p>
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Objective@#This study aims to determine the convergent and discriminant validity and internal consistent reliability of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ-C30) Tagalog among adult Filipinos with differentiated thyroid cancer (DTC).@*Methodology@#104 adult Filipinos with DTC at various disease stages self-administered the EORTC QLQ-C30 version 3 Tagalog and Short Form-36 (SF-36) version 2 Tagalog. Concurrent validity between conceptually-related scales from both tools was determined. Convergent and discriminant validity of multi-item scales of the EORTC QLQ-C30 Tagalog were assessed by Spearman’s correlation. Cronbach's α was computed.@*Results@#The EORTC QLQ-C30 Tagalog showed moderate correlation with similar scales in the SF-36 Tagalog particulary for physical, role and social functioning, pain, and global health (r=0.42-0.48, p<0.001). It showed satisfactory item-domain convergent and discriminant validity for all scales except pain, fatigue, physical and cognitive functioning. Internal consistent reliability was good with cronbachs α ranging from 0.77 to 0.88 for global health, emotional and role functioning and symptom scale of nausea/vomiting.@*Conclusion@#The EORTC QLQ-C30 Tagalog had acceptable convergent and discriminant validity and internal consistent reliability for the scales of global health, role, social and emotional functioning and nausea/vomiting when applied among adult Filipinos with DTC.
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Thyroid Neoplasms , Quality of Life , Validation StudyABSTRACT
Introduction: Malnutrition among cancer patients is associated with a higher risk of gastrointestinal toxicity which develops during treatment and may affect quality of life (QOL). Thus, this cross-sectional study aimed to determine the nutritional status and QOL of 30 oncology patients (mean age 50.0+10.7 years) prior to pelvic radiotherapy at Hospital Sultan Ismail, Johor Bahru. Methods: Patients were assessed for anthropometry measurements, 24-h diet recall and nutritional status using Scored Patient-Generated Subjective Global Assessment (PG-SGA) questionnaire while the European Organization for Research and Treatment of Cancer Care Quality of Life Questionnaire (EORTC QLQ-C30) was used to assess QOL two weeks prior to the initiation of pelvic radiotherapy. Results: Mean Body Mass Index (BMI) of patients was 23.3+3.3kg/m2 and 33% of patients experienced weight loss prior to pelvic radiotherapy. The PG-SGA rating indicated that 63% of patients were at Stage A (well-nourished) and 37% were in Stage B (moderate malnutrition). The PG-SGA numerical score was a significant predictor of QOL, after adjusting for socio-demographic factors (R2=0.861, p<0.05). Conclusion: In general, the low nutritional status of the patients indicates the need for early nutritional assessment, education and intervention in ensuring optimal nutritional status throughout the pelvic radiotherapy treatment.
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ObjectiveBy observing and comparing the effect of wheat-sized moxibustion on the quality of life and interleukin (IL)-10 expression in stageⅢ~Ⅳtumor patients of two different traditional Chinese medicine (TCM) patterns by using QLQ-C30 questionnaire, to see whether wheat-sized moxibustion can improve the quality of life, regulate oncology-related immune system, and enhance the survival rate of the stageⅢ~Ⅳtumor patients.MethodForty-two tumor patients were randomized into a treatment group and a control group and were differentiated into TCM patterns. The treatment group was intervened by conventional Chinese and Western medicine plus 2 weeks of wheat-sized moxibustion. QLQ-C30 questionnaire was adopted for evaluation before and after treatment, and peripheral blood was drawn to detect the expression of IL-10.ResultWheat-sized moxibustion improved the quality of life, especially fatigueand poor appetite; the expression of IL-10 dropped after wheat-sized moxibustion.Conclusion Wheat-sized moxibustion can improve the quality of life of the tumor patients and down-regulate the expression of IL-10.
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Aims: To assess the Quality of Life (QOL) among female breast cancer patients in a university hospital in Malaysia. Study Design: The study was designed as a cross-sectional study. Place and Duration of Study: The study was conducted at the Surgery and Oncology Clinic in University Kebangsaan Malaysia Medical Centre (UKMMC) between 22nd May 2014 and 27th June 2014. Methodology: A total of 133 female breast cancer patients were selected by universal sampling, out of which 117 patients responded. The QOL was measured both by the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire C30 (EORTC QLQ-C30) and breast cancer specific supplementary module (QLQ-BR23). Results: The global health status/QOL mean score was 67.81 (SD±18.92). Mean age of the respondent was 54 years (SD±18.39). Nearly half of the Malay breast cancer patients (45.6%) diagnosed at the stage of III & IV. In the functional scales, the highest mean score was observed for cognitive functioning 83.19 (SD±22.26); whereas emotional functioning had the lowest mean score 62.96 (SD±26.39). The respondents were satisfied with their body image with a mean score of 81.34 (SD±24.26) but greatly affected by sexual functioning with a mean score of 31.48 (SD±26.96). Most prevalent general symptoms reported in this study were fatigue, insomnia, pain, appetite loss and financial difficulties; and most prevalent breast cancer specific symptom was found upset by hair loss. Conclusion: Specific measures should be taken for the routine breast cancer screening, awareness and education programmes to promote early detection and diagnosis of the breast cancer. The planned rehabilitation protocol should be addressed by health care professionals to further improve the QOL among breast cancer patients.
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BACKGROUND: The study examined the correlations among the results of the European Organization for Research and Treatment of Cancer (EORTC)-Quality of Life Questionnaire, Core 30 (QLQ-C30) completed by elderly cancer patients and their family caregivers and the Eastern Cooperative Oncology Group (ECOG)-performance status (PS) evaluated by medical doctors. METHODS: The study sample included 269 persons with cancer aged 55 years or older and their family caregivers recruited from hospitals located in Seoul and Gyeonggi-do. The results of the ECOG-PS evaluated by medical doctors were obtained from medical records. Intra-class correlation analysis was used to assess rater reliability between the elderly cancer patients and their family caregivers. Correlations among the EORTC QLQ-C30 and the ECOG-PS were tested using the Kruskal-Wallis test and Spearmen's correlation. RESULTS: The results showed that four subscales of quality of life (physical functioning, emotional functioning, social functioning, and global health status) and three items under symptoms (fatigue, pain, and financial difficulties) in the EORTC QLQ-C30 were highly consistent between patients and their family caregivers. From the EORTC QLQ-C30 results, social functioning, role functioning, health status, fatigue, pain, and appetite loss (patients results) and physical functioning (family caregivers results) were highly consistent with the results of the ECOG-PS by the physicians. CONCLUSIONS: The findings suggest that when the older persons with cancer have difficulty expressing their own thoughts or feelings, the EORTC QLQ-C30 completed by their family caregivers and the results of the ECOG-PS completed by the physicians could be used as substitutes.
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Aged , Humans , Appetite , Caregivers , Fatigue , Medical Records , Medical Staff , Quality of Life , SeoulABSTRACT
OBJECTIVES: 1) To characterize the impact of multiple myeloma on the quality of life of patients treated in two public institutions in São Paulo State, Brazil, using a generic Short Form 36 Health Survey and a questionnaire specific for oncologic patients (QLQ-C30) upon diagnosis, after the clinical treatment, and at day +100 after autologous stem cell transplantation; 2) to evaluate whether autologous stem cell transplantation can improve the quality of life of our economically challenged population aside from providing a clinical benefit and disease control. METHODS: We evaluated 49 patients with multiple myeloma (a total of 70 interviews) using the two questionnaires. The scores upon diagnosis, post-treatment/pre-autologous stem cell transplantation, and at D+100 were compared using ANOVA (a comparison of the three groups), post hoc tests (two-by-two comparisons of the three groups), and paired t-tests (the same case at two different times). RESULTS: Of the included patients, 87.8 percent had a family budget under US $600 (economic class C, D, or E) per month. The generic Short Form 36 Health Survey questionnaire demonstrated that physical function, role-physical, and bodily pain indices were statistically different across all three groups, favoring the D+100 autologous stem cell transplantation group (ANOVA). The questionnaire specific for oncologic patients, the QLQ-C30 questionnaire, confirmed what had been demonstrated by the Short Form 36 Health Survey with respect to physical function and bodily pain, with improvements in role functioning, fatigue, and lack of appetite and constipation, favoring the D+100 autologous stem cell transplant group (ANOVA). The post hoc tests and paired t-tests confirmed a better outcome after autologous stem cell transplantation CONCLUSION: The questionnaire specific for cancer patients seems to be more informative than the generic Short Form 36 Health Survey questionnaire and reflects the real benefit of autologous stem cell transplantation in the quality of life of multiple myeloma patients in two public Brazilian institutions that provide assistance for economically challenged patients.
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Female , Humans , Male , Middle Aged , Budgets/statistics & numerical data , Multiple Myeloma/surgery , Quality of Life , Social Class , Stem Cell Transplantation , Brazil , Epidemiologic Methods , Multiple Myeloma/physiopathology , Transplantation, Autologous , Treatment OutcomeABSTRACT
Background and purpose: Most of the patients with esophageal cancers were late stage cases when diagnosed clinically. Since the prognosis is very poor, it is extremely important to improve the quality of life (QOL) of these patients. Concurrent chemoradiotherapy is an effective modality for esophageal cancer. However, effects on quality of life of chemoradiotherapy are rarely reported domestically. Our purpose was to assess the immediate effect on the quality of life in patients with primary esophageal carcinoma. Methods: QOL was assessed by the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30) Chinese edition. Fifty-two patients were randomized to receive either concurrent chemoradiotherapy (CRT) or late course accelerated hyperfractionated radiotherapy (LAHF). QOL questionnaires were given before therapy and at the 4th week during radiotherapy, the completion of radiotherapy, and then after 1 and 3 months after the completion of radiotherapy, respectively. Results: It has been observed that the scores of global health status, physical functioning,role functioning and social functioning during the radiotherapy and from completion of radiotherapy to 1 month post radiotherapy in CRT and LAHF groups, deteriorated temporarily, but it were not significant when compared with those before radiotherapy (P>0.05). However, global health status scores, physical functioning scores, role functioning scores were significantly improved in patients who received CRT at 3 months post radiotherapy. Mean scores were improved by 12.0±3.7 (P=0.012),8.1±2.9 (P=0.023) and 14.8±5.2 (P=0.015), respectively. Nausea and vomiting, pain and appetite loss scales scores rapidly recovered to the baseline level after therapy, although they were worsened during therapy.Conclusion: Global health status scores, physical functioning scores and role functioning scores were significantly improved at 3 months after radiotherapy in patients treated by CRT. In terms of QOL, CRT is a feasible modality for esophageal cancer.
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Objective To observe the influence of Bailong Jieyu Granules on quality of life (QOL) of patients with cancer-ralated depression. Methods A prospective and self-control clinical trial was carried out. Sixty seven patients with cancer-ralated depression were chosen and treated with Bailong Jieyu Granules. EORTC QLQ-C30 3.0 scores of patients were assessed before and after the treatment. Results After treatment of Bailong Jieyu Granules, the scores of role function, emotional function and global quality of life were increased, while the scores of fatigue, nausea/vomiting, insomnia and appetite loss were decreased, there were significant differences (P